Report Viewer

NINDS CDE Notice of Copyright
Non-Motor Symptom Questionnaire (NMS-Quest) (PD-NMS)
Availability
Please visit this website for more information about the instrument: Non-Motor Symptoms Questionnaire
Classification
Supplemental: Parkinson's Disease (PD)
Short Description of Instrument
The Non-motor Symptoms Questionnaire (NMS-Quest) (PD-NMS) is a self-completed patient questionnaire with 30 qualitative questions designed to identify the presence but not the severity of non-motor symptoms.
Scoring and Psychometric Properties
Scoring: Each of the 30 questions presents a problem that patients may have experienced within the past month. The patients may give an answer of "yes", "no", or "don't know" to each of the 30 questions.
 
Suggested scoring scheme: 0 = No NMS; 1-5 = Mild; 6-9 = Moderate; 10-13 = Severe; and >13 = Very severe
 
Psychometric Properties: Low ceiling and floor effects; strong correlation with H&Y stage; 75% of PD caregivers and patients felt NMSQuest helped doctors treat PD better, while over 90% reported that the items contained in the NMSQuest were appropriate and relevant to day-to-day life.
Rationale/Justification
Strengths: PD-specific scale, brief administration time (5-7 minutes), self-administered, validated in multiple languages, and initially developed by an international multicenter collaboration.
 
Weaknesses: Developed as a screening questionnaire rather than an outcome measure for severity or progression of disease.
References
Key Reference:
Chaudhuri KR, Martinez-Martin P, Schapira AH, Stocchi F, Sethi K, Odin P, Brown RG, Koller W, Barone P, MacPhee G, Kelly L, Rabey M, MacMahon D, Thomas S, Ondo W, Rye D, Forbes A, Tluk S, Dhawan V, Bowron A, Williams AJ, Olanow CW. International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson's disease: the NMSQuest study. Mov Disord. 2006 Jul;21(7):916-23.
 
Additional References:
Chaudhuri KR, Sauerbier A, Rojo JM, Sethi K, Schapira AH, Brown RG, Antonini A, Stocchi F, Odin P, Bhattacharya K, Tsuboi Y, Abe K, Rizos A, Rodriguez-Blazquez C, Martinez-Martin P. The burden of non-motor symptoms in Parkinson's disease using a self-completed non-motor questionnaire: a simple grading system. Parkinsonism Relat Disord. 2015 Mar;21(3):287-91.
 
Li HJ, Zhang MF, Chen MX, Hu AL, Li JB, Zhang B, Liu W. Validation of the nonmotor symptoms questionnaire for Parkinson's disease: results from a Chinese pilot study. Int J Neurosci. 2015;125(12):929-35
 
Martinez-Martin P, Schapira AH, Stocchi F, Sethi K, Odin P, MacPhee G, Brown RG, Naidu Y, Clayton L, Abe K, Tsuboi Y, MacMahon D, Barone P, Rabey M, Bonuccelli U, Forbes A, Breen K, Tluk S, Olanow CW, Thomas S, Rye D, Hand A, Williams AJ, Ondo W, Chaudhuri KR. Prevalence of nonmotor symptoms in Parkinson's disease in an international setting; study using nonmotor symptoms questionnaire in 545 patients. Mov Disord. 2007 Aug 15;22(11):1623-9.
 
Perez LS, Rossi M, Cardinali DP, Merello M. Validation of the sleep related items of the Non-motor Symptoms Questionnaire for Parkinson's disease (NMSQuest). Parkinsonism Relat Disord. 2008 Dec;14(8):641-5.
 
Storch A, Odin P, Trender-Gerhard I, Fuchs G, Reifschneider G, Ray Chaudhuri K, Jost WH, Ebersbach G. Non-motor Symptoms Questionnaire und Scale für das idiopathische Parkinson-Syndrom. Interkulturell adaptierte Versionen in deutscher Sprache [Non-motor Symptoms Questionnaire and Scale for Parkinson's disease. Cross-cultural adaptation into the German language]. Nervenarzt. 2010 Aug;81(8):980-5. German.
 
Document last updated August 2022